On December 24, 2012, Jake Muller, a mercenary of the fictional South-Slavic Edonian Liberation Army and son of late bio-terrorist Albert Wesker,
flees from the authorities during a bio-terrorist attack. He partners
up with Division of Security Operations (DSO) agent and Raccoon City
survivor Sherry Birkin,
who was sent to Edonia to ensure that Jake escapes safely from the
country so his blood can be tested for anti-bodies for the newly
developed C-Virus. At the same time, Bio-terrorism Security Assessment
Alliance (BSAA) Captain Chris Redfield
and his team, including sniper Piers Nivans and demolitions expert Finn
Macauley fight against rebels infected with the C-Virus (referred to as
"J'avo") and two large B.O.W.'s referred to as "Ogromans". However,
they are attacked by the leader of Neo-Umbrella, who refers to herself as Ada Wong
and kills most of the BSAA members using a device that injects them
with the C-virus turning them into monsters, except Chris and Piers. The
aftermath causes Chris to go into self-imposed exile, being afflicted
with post-traumatic amnesia.
Meanwhile, Sherry and Jake's extraction from Edonia by the BSAA is
sabotaged by a BOW codenamed 'Ustanak', forcing the pair to crash into
the mountains, eventually leading to their capture by Ada.
On June 29, 2013, U.S. President
Adam Benford has decided to officially reveal the truth behind the 1998
Raccoon City incident and the U.S. federal government's dealings with
Umbrella, believing that it will curb the current resurgence in
bio-terrorist activity.[8] By the President’s side is his friend, DSO agent and Raccoon City survivor Leon S. Kennedy and United States Secret Service
agent Helena Harper, but when the venue becomes host to another
bio-terrorist attack, Leon is forced to face the infected and mutated
President, and kill him.[9]
Helena leads Leon to the Tall Oaks Cathedral amidst the zombie outbreak
to rescue her sister, Deborah. By the time the pair reaches Deborah,
she had already been infected with the C-virus, and the pair are forced
to kill her. Along the way, the two encounter Ada, and Helena then
discloses to Leon that she was blackmailed by National Security Advisor
Derek C. Simmons, into aiding the assassination of Benford. She also
discloses Simmons's affiliation with Neo-Umbrella. Shortly after
escaping the Cathedral, Tall Oaks is destroyed by an airstrike. Leon and
Helena then decide to pursue Simmons into Lanshiang, China (the city's
background is based on Hong Kong) while faking their deaths with aid from Ingrid Hunnigan. Meanwhile, Jake and Sherry manage to escape captivity in Lanshiang after being held captive for 6 months.
At the same time, Chris returns to duty in the BSAA with Piers and a
new team, arriving in Lanshiang under the threat of a bio-terrorist
attack. Chris recovers from his amnesia and goes on a vendetta against
Ada, resulting in mounting casualties for his squad. Chris and Piers
corner Ada, until Leon intervenes. After being updated by Leon, Chris
and Piers pursue Ada to an aircraft carrier, destroying cruise missiles
laden with the C-virus, while an assassin apparently kills Ada. Leon,
Helena, Sherry, and Jake confront Simmons over his involvement with the
outbreaks, where Sherry covertly hands Jake's medical data to Leon in
case of their captivity. Leon and Helena corner Simmons, who has been
infected by a J'avo, atop a train, where he confesses to having killed
the President to keep him from disclosing the truth behind Raccoon City,
which would have led to the U.S. losing its authority. The two
temporarily defeat a mutated Simmons while Sherry and Jake are captured
once again. While attempting to leave the city, Leon and Helena are
warned by Chris that a missile has been launched, but they are too late
to stop it. Leon discloses Jake's real identity to Chris and has him
rescue Jake and Sherry in a remote oil platform. With the assistance of
Ada, Leon and Helena finally kill Simmons before escaping with evidence
proving Simmons's crimes provided by Ada, exonerating Helena.
In the oil platform, Chris and Piers head underground, managing to
free Jake and Sherry from captivity before preventing a large-scale BOW
attack from the location. When they meet up briefly, Chris reveals to
Jake that he was the one who killed his father, but Jake resists the
urge to kill him, saying that there are more important things than his
want for revenge. Jake and Sherry manage to finally kill 'Ustanak' once
and for all during their escape, securing a steady supply of the C-virus
vaccine while Chris and Piers fight the host BOW, Haos. Heavily
wounded, and in a desperate attempt to save Chris, Piers injects himself
with a sample of the C-virus to help turn the tide of the battle,
temporarily defeating Haos before evacuating. Aware that the mutation
would worsen, Piers sacrifices himself by pushing Chris to an escape
pod. After Chris' pod is launched, Haos makes one last attempt to kill
Chris but is killed itself by a powerful lightning charge from Piers,
which ensures Chris' escape and the destruction of the Neo-Umbrella
base.
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